International Screening Limits in urine and signatory countries in the Asian region


Updated 21 September 2017

Substances ISL in urine* Codes of Signatory Countries#
Betamethasone 0.2 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Dembrexine 100 BH, HK, IN, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Diclofenac 50 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, PK, QA, SA, ZA, TH, TR, AE, VN
Dipyrone 1000 ng/mL of 4-methyl-amino-antipyrene AU, BH, HK, IN, JP, KR, MO MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Flunixin 100 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, PK, QA, SA, ZA, TH, TR, AE, VN
Furosemide 50 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, PK, QA, ZA, TH, TR, AE, VN
Hyoscine-N-butylbromide (N-butylscopolammonium) 25 AU, BH, HK, IN, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Ipratropium 0.25 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Ketoprofen 100 AU, BH, HK, IN, JP, MO, MY, MU, MN, NZ, PK, QA, SA, ZA, TH, TR, AE, VN
Lidocaine 10 ng/mL of the 3'-hydroxy-lidocaine AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Meloxicam 10 n AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, PK, QA, SA, ZA, TH, TR, AE, VN
Mepivacaine 10 ng/mL of the 3'-hydroxy-mepivacaine AU, BH, HK, IN, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Triamcinolone acetonide 0.5 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, PK, QA, SA, ZA, TH, TR, AE, VN
Acepromazine 10 ng/mL of 2-(1-hydroxyethyl)promazine sulfoxide AU, BH, HK, KR, IN, MO, MY, MU, MN, SA, QA, ZA, AE, VN
Bromhexine 200 ng/mL of ambroxal BH, HK, IN, KR, MO, MY, MU, MN, QA, SA, ZA, AE, VN
Carprofen 100 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, QA, SA, ZA, AE, VN
Detomidine 2 ng/mL of 3’-hydroxydetomidine AU, BH, HK, IN, KR, MO, MY, MU, MN, QA, ZA, SA, AE, VN
Eltenac 50 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, QA, SA, ZA, AE, VN
Meclofenamic acid 250 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, QA, SA, ZA, AE, VN
Naproxen 250 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, QA, SA, ZA, AE, VN
Phenylbutazone 100 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, NZ, QA, AE, VN
Vedaprofen 50 AU, BH, HK, IN, JP, KR, MO, MY, MU, MN, QA, SA, ZA, AE, VN
Butorphanol 1 AU, BH, HK, IN, KR, MO, MY, MU, PK, QA, SA, ZA, TM, TR, AE, VN
Romifidine 1 AU, BH, HK, IN, KR, MO, MU, PK, QA, SA, ZA, TM, TR, AE, VN
Salbutamol 0.5 AU, BH, HK, IN, JP, KR, MO, MU, PK, QA, SA, ZA, TM, TR, AE, VN
Dantrolene 1 ng/mL of 5-hydroxydantrolene in unhydrolysed urine AU, HK, KR, MO, MY, MU, PK, SA, ZA, TH, TR, AE, VN
Dexamethasone 0.2 AU, HK, JP, KR, MO, MY, MU, PK, SA, ZA, TH, TR, AE, VN
Omeprazole 0.5 ng/mL in unhydrolysed urine HK, MO, MY, MU, PK, SA, TH, TR, AE, VN
Medetomidine 5 ng/mL of 3'-hydroxymedetomidine AU, HK, JP, MU
Clenbuterol 0.1 HK, JP, MU



International Screening Limits (ISL) - Definition and Recommendations for their Application in the control of Therapeutic Substances:
Substances prohibited in racing are defined in Clause 10 of Article 6 of the International Agreement on Breeding, Racing and Wagering; accordingly therapeutic substances used for the treatment of racehorses are covered within this definition and prohibited by the rules of racing at all concentrations. In order for laboratories to report the presence of certain therapeutic substances in a consistent manner, International Screening Limits (ISLs) have been agreed for these substances.

The ISL is the urine or plasma concentration adopted for the screening of a specified therapeutic prohibited substance; it is derived from administration studies followed by a risk analysis consisting of two components: a risk assessment (evaluation of the effect of the substance and factors related to its control) and a risk management (decision step for harmonisation). ISLs are harmonised detection limits agreed following input by international consensus and are conveyed by instruction from racing authorities to their laboratories. The ISLs are simply the detection limits to be used by the laboratories when screening for certain therapeutic substances as instructed by the authorities; they are not international thresholds. When the screening procedure indicates the ISL has been exceeded, all that is required is qualitative confirmatory analysis (usually by mass spectrometry) to confirm the presence or absence of the prohibited substance. Quantification is not required.

'*Explanatory Notes:


'# Signatory countries that have adopted the individual ISL.

ARF Country codes: AU = Australia; BH = Bahrain; HK = Hong Kong; IN = India; JP = Japan; KR = Korea; MO = Macau; MY = Malaysia; MU = Mauritius; MN = Mongolia; NZ = New Zealand; OM = Oman; PK = Pakistan; PH = Philippines; QA = Qatar; SA = Saudi Arabia; SG = Singapore; ZA = South Africa; TH = Thailand; TM = Turkmenistan; TR = Turkey; AE = United Arab Emirates; VN = Vietnam.